The industrialization of biologyoffers far-reaching benefits at both the globaland the national scale. Today, the focus is to improve efficacy and robustness of microbial cell factories, suitable for industrial production of products in health industry and others. Strain engineering is to be done to improve the existing either by mutagenesis or advanced targeted methods. If Industrial Biotechnology is used to its full potential, it would be the best tool towards a sustainable bio-economy.