Bio-catalysiscan be explained as the use of natural products like one or more enzymes or cells to speed up (or catalyse) chemical reactions. The success of bio-catalysis depends on protein engineering, and enzyme immobilization. Immobilization can play an important role in the adoption of bio-catalytic processes. By switching to bio-catalysis as the main technology for chemical production, it will lead to green processing, reduces pollution and cost, and help towards bio-economy. Bio-catalysis will help in increasing the ability to use enzymes to catalyze chemical reactions in industrial biotechnology.